SOURCE: Protherics PLC

January 30, 2007 13:01 ET

Protherics PLC announces Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- January 30, 2007 --

                                 Protherics PLC



                    Notification of Major Interest in Shares





London, UK; Brentwood, TN, US; 30 January 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that the following notification of interest in the
ordinary share capital of the Company was received on 29 January 2007 from Aviva
plc.




1. Reason for the notification     (please tick the appropriate box or boxes)
An acquisition or disposal of voting rights                                                X
An acquisition or disposal of financial instruments which may result in the acquisition
of shares already issued to which voting rights are attached
An event changing the breakdown of voting rights
Other (please specify):_________________________________
2. Full name of person(s) subject to the                    Aviva plc & its subsidiaries
notification obligation:
3. Full name of shareholder(s) (if different from Registered Holder:
2.):


                                                  BNY Norwich Union Nominees Limited

                                                   5,501,445*



                                                  Chase GA Group Nominees Limited
                                                  12,487,213*



                                                  Chase Nominees Limited
                                                  699,009*



                                                  CUIM Nominee Limited
                                                  4,905,449*



                                                  Vidacos Nominees Limited
                                                  86,079*



                                                  BNP Paribas - London
                                                  1,000,000



                                                  Chase Nominees Limited
                                                  675,775



                                                  CUIM Nominee Limited
                                                  3,550,079



                                                  State Street Nominees Limited
                                                  5,194,498



                                                  Vidacos Nominees Limited
                                                  5,741,350

                                                  *denotes direct interest


4. Date of the transaction (and date on which the 25 January 2007
threshold is crossed or reached if different):

5. Date on which issuer notified:                 29 January 2007

6. Threshold(s) that is/are crossed or reached:   7% to 6% Change at Direct Interest level


7. Notified details:




A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
                  transaction
if possible using Number of   Number of    Number of     Number of voting rights     % of voting
the ISIN CODE     Shares      Voting       shares                                    rights
                              Rights       Direct        Direct        Indirect      Direct   Indirect
Ordinary Shares



GB0007029209      40,095,830  40,095,830   23,679,195    23,679,195    16,161,702    6.98%    4.77%








B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial   Expiration date Exercise/ Conversion      Number of voting rights    % of voting
instrument                          Period/ Date              that may be acquired if    rights
                                                              the instrument is
                                                              exercised/ converted.


                                                  N/A


Total (A+B)
Number of voting rights                           % of voting rights


39,840,897                                        11.75%


8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable :
                                                  See Section 3


Proxy Voting:
9. Name of the proxy holder:                                           See Section 3
10. Number of voting rights proxy holder will cease to hold:
11. Date on which proxy holder will cease to hold voting rights:


12. Additional information:                Figures are based on a total number of voting rights  of
                                           338,976,174







                                   |  Ends  |





For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs                                     +44 (0) 7919  480510
Julie Vickers, Company Secretary                                                +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                                                 +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                                         +1 212 850 5600



Or visit  www.protherics.com




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            The company news service from the London Stock Exchange