SOURCE: Protherics PLC

February 26, 2008 10:58 ET

Protherics PLC announces Holding(s) in Company

Cheshire, UK--(Marketwire - February 26, 2008) -

                                Protherics PLC

                   Notification of Major Interests in Shares



London, UK; Brentwood, TN, US: 26 February 2008 - Protherics PLC ("Protherics"
or the "Company"), the international biopharmaceutical company focused on
critical care and cancer, announces that, on 25 February 2008, in accordance
with the Transparency Obligations Directive, a notification of interest in the
ordinary share capital of the Company was received from AXA Investment Managers
UK Limited on behalf of AXA S.A. and its Group Companies ("AXA").  Details of
the notification are as follows:


1. Reason for the notification (please tick the appropriate box or boxes)


An acquisition of voting rights                                           X


An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached


An event changing the breakdown of voting rights


Other (please specify):


2. Full name of person(s) subject to the           AXA S.A., 25 Avenue Matignon, 75008 Paris and its
notification obligation:                                          group of companies.



3. Full name of shareholder(s) (if different
from 2.):



4. Date of the transaction (and date on which                       24 February 2008
the threshold is crossed or reached if
different):



5. Date on which issuer notified:                                   25 February 2008



6. Threshold(s) that is/are crossed or reached:                           13%



7. Notified details:



A: Voting rights attached to shares

Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
                  transaction

if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect


0702920           44,103,463  44,103,463   741,666       741,666       43,692,111    0.22%     12.85%






B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.






Total (A+B)

Number of voting rights                   % of voting rights

44,433,777                                13.07%




8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable :


   Name of Company/Fund                           Number of Shares       % of issued share capital


AXA UK Investment Co ICVC                                  574,090               0.16887
UK Smaller Companies Fund
                 Indirect

Sun Life Pensions Management Ltd                            25,000               0.00735
                 Direct

Sun Life Unit Assurance Ltd                                 53,913               0.01586
FTSE All Share Tracker Life
                 Direct

Sun Life Pensions Management                               294,874               0.08674
FTSE All Share Tracker
                 Direct

AXA Framlington                                            850,000               0.25003
SEI UK Equity
                 Indirect

AXA Framlington                                          1,851,468               0.54462
St James Place Exempt (Pens) Fund
                 Indirect

AXA Framlington                                          1,909,918               0.56181
St James Place Net (Life) Fund
                 Indirect


AXA Framlington                                            459,865               0.13527
St James Place Offshore Fund
                 Indirect

AXA Framlington                                            639,353               0.18807
Daimler Chrysler
                 Indirect

AXA Framlington                                          3,120,333               0.91787
Throgmorton Trust
                 Indirect

AXA Framlington                                         15,013,453               4.41630
UK Select Ops
                 Indirect

AXA Framlington                                         13,753,131               4.04557
Equity Income
                 Indirect

AXA Framlington                                          2,000,000               0.58831
Managed Balanced
                 Indirect

AXA Framlington                                          1,500,000               0.44123
UK Smaller Companies
                 Indirect

AXA Framlington                                            500,000               0.14708
BAE Systems Pensions Fund CIF Trustees
                 Indirect

AXA Framlington                                            220,000               0.06471
BAE Systems 2000 Pensions Fund
                 Indirect

Framlington onshore private clients                        975,500               0.28695
                 Indirect

Axa Sun Life With Profits Passive                          226,817               0.06672
                 Direct

Axa Sun Life With Profits Passive                          141,062               0.04149
                 Direct

AXA Framlington                                            325,000               0.09560
St James Place Internal Equity & Income UT
                Indirect


                                      Total Direct         741,666               0.21817

                                    Total Indirect      43,692,111              12.85230

                                             TOTAL      44,433,777              13.07047




Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting
rights:


12. Additional information:


                                   |  Ends  |


For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs                 +44 (0) 7919  480510
Julie Vickers, Company Secretary                            +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                               +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                     +1 212 850 5600



Or visit  www.protherics.com


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