SOURCE: Protherics PLC

August 14, 2008 12:11 ET

Protherics PLC announces Holding(s) in Company

Cheshire, UK--(Marketwire - August 14, 2008) -


Protherics PLC


Notification of Major Interest in Shares



London, UK; Brentwood, TN, US; 14 August 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that, on 12
August 2008, the following notification of interest in the ordinary
share capital of the Company was received today from Aviva plc.



1. Reason for the notification     (please tick the
appropriate box or boxes)

An acquisition  voting rights 
                                                       x

An acquisition or disposal of financial instruments
which may result in the acquisition of shares already
issued to which voting rights are attached

An event changing the breakdown of voting rights


Other (please specify): CHANGE TO THE TOTAL NUMBER OF
VOTING RIGHTS IN ISSUE

2. Full name of person(s) subject to the             Aviva plc & its
notification obligation:                             subsidiaries   

3. Full name of shareholder(s) (if different from    Registered Holder:
2.):

                                                     BNY Norwich Union
                                                     Nominees Limited
                                                     6,741,190*

                                                     Chase GA Group
                                                     Nominees Limited
                                                     18,382,959*


                                                     Chase Nominees
                                                     Limited
                                                     979,009*   


                                                     CUIM Nominee
                                                     Limited
                                                     4,812,551*

                                                     Vidacos Nominees
                                                     Limited
                                                     70,303*


                                                     BNP Paribas
                                                     - London
                                                     636,429


                                                     Chase Nominees
                                                     Limited 
                                                     3,518,325


                                                     State Street
                                                     Nominees Limited  
                                                     9,577,375


                                                     Vidacos Nominees
                                                     Limited 
                                                     2,003,920                                   *denotes direct
                                                     interest  


4. Date of the transaction (and date on which the    11 August 2008   
threshold is crossed or reached if different):

5. Date on which issuer notified:                    12 August 2008   

6. Threshold(s) that is/are crossed or reached:      8% to 9% Change
                                                     at Direct Interest
                                                     level   


7. Notified details:




A: Voting rights attached to shares

Class/type    Situation previous      Resulting situation after the
of shares     to the Triggering       triggering transaction
              transaction 
if possible
using the     Number    Number         Number     Number of      
              of           of          of         voting
ISIN CODE     Shares    Voting         shares     rights
                        Rights                      
                                       Direct     Direct   Indirect 
Ordinary
Shares
GB0007029209 46,151,488  46,151,488    30,986,012 30,986,012 15,736,049

                                                   % of voting rights
                                                    Direct    Indirect

                                                    9.06 %     4.60%


B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted. 


N/A



Total (A+B)

Number of voting rights % of voting rights

46,722,061              13.66%




8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

See Section 3



Proxy Voting:

9. Name of the proxy holder:                                See
                                                         Section 3

10. Number of voting rights proxy holder will cease to      
hold:

11. Date on which proxy holder will cease to hold voting    
rights:



12. Additional       Figures are based on a total number of voting
information:         rights of 342,159,034





/ Ends /



For further information please contact:


Protherics 

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510
Julie Vickers, Company Secretary            +44 (0)1928 518010


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113
New York: John Capodanno                    +1 212 850 5600

Or visit  www.protherics.com


                    This information is provided by RNS
          The company news service from the London Stock Exchange

END

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