SOURCE: Protherics PLC

September 09, 2008 15:21 ET

Protherics PLC Announces Holding(s) in Company

Cheshire, UK--(Marketwire - September 9, 2008) -

Protherics PLC

Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 9 September 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that on 
8 September 2008, in accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share
capital of the Company was received from AXA Investment Managers UK
Limited on behalf of AXA S.A. and its Group Companies ("AXA").  The
notification follows a change in AXA's Indirect Voting Rights.  
Details of the interest notified are as follows:

1.    Reason for the notification (please tick
the appropriate box or boxes)    

A disposal of voting rights                      X

An acquisition or disposal of financial
instruments which may result in the acquisition
of shares already issued to which voting rights
are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the      AXA S.A., 25 Avenue
notification obligation:                      Matignon, 75008 Paris and
                                              its group of companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which 7 September 2008
the threshold is crossed or reached if

5. Date on which issuer notified:             8 September 2008

6. Threshold(s) that is/are crossed or        12%

7. Notified details:

A: Voting rights attached to shares

Class/    Situation previous         
type of   to the Triggering        
shares    transaction                           
using     Number     Number     
the ISIN  of         of Voting       
CODE      Shares     Rights       

0702920   42,118,236 42,118,236 

Class/                 Resulting situation after
type of                the triggering transaction
the ISIN
CODE              Number       Number of voting       % of voting
                  of shares    rights                    rights

                  Direct       Direct  Indirect    Direct   Indirect

0702920        1,041,666    1,041,666 41,063,106   0.30%    12.00%

B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted. 

Total (A+B)

Number of voting rights % of voting rights

42,104,772              12.30%

8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

Name of Company/Fund                    Number of   % of issued share
                                        Shares      capital

AXA                                     716,666     0.20943   


AXA Framlington                         40,572,688  11.85629


AXA IM Paris                            490,418     0.14331


AXA IM UK                               325,000     0.09497


Total Direct                            1,041,666   0.30440

Total Indirect                          41,063,106  11.99960

TOTAL                                   42,104,772  12.30400

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will
cease to hold:

11. Date on which proxy holder will cease to hold
voting    rights:

12. Additional information:

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600

Or visit

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