Protherics PLC Notification of Major Interests in Shares London, UK; Brentwood, TN, US: 9 September 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that on 8 September 2008, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from AXA Investment Managers UK Limited on behalf of AXA S.A. and its Group Companies ("AXA"). The notification follows a change in AXA's Indirect Voting Rights. Details of the interest notified are as follows: 1. Reason for the notification (please tick the appropriate box or boxes) A disposal of voting rights X An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify): 2. Full name of person(s) subject to the AXA S.A., 25 Avenue notification obligation: Matignon, 75008 Paris and its group of companies. 3. Full name of shareholder(s) (if different from 2.): 4. Date of the transaction (and date on which 7 September 2008 the threshold is crossed or reached if different): 5. Date on which issuer notified: 8 September 2008 6. Threshold(s) that is/are crossed or 12% reached: 7. Notified details: A: Voting rights attached to shares Class/ Situation previous type of to the Triggering shares transaction if possible using Number Number the ISIN of of Voting CODE Shares Rights 0702920 42,118,236 42,118,236 Class/ Resulting situation after type of the triggering transaction shares if possible using the ISIN CODE Number Number of voting % of voting of shares rights rights Direct Direct Indirect Direct Indirect 0702920 1,041,666 1,041,666 41,063,106 0.30% 12.00% B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that % of financial date Conversion may be acquired if the voting instrument Period/ instrument is exercised/ rights Date converted. Total (A+B) Number of voting rights % of voting rights 42,104,772 12.30% 8. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable : Name of Company/Fund Number of % of issued share Shares capital AXA 716,666 0.20943 Direct AXA Framlington 40,572,688 11.85629 Indirect AXA IM Paris 490,418 0.14331 Indirect AXA IM UK 325,000 0.09497 Direct Total Direct 1,041,666 0.30440 Total Indirect 41,063,106 11.99960 TOTAL 42,104,772 12.30400 Proxy Voting: 9. Name of the proxy holder: 10. Number of voting rights proxy holder will cease to hold: 11. Date on which proxy holder will cease to hold voting rights: 12. Additional information: / Ends / For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange END
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