SOURCE: Protherics PLC

January 08, 2007 13:29 ET

Protherics PLC announces Interest in Shares

Cheshire, UK -- (MARKET WIRE) -- January 8, 2007 --

                                 Protherics PLC

                       Notification of Interest in Shares

London, UK; Brentwood, TN, US; 8 January 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, today announces that on 5 January 2007, notification was
received from Perpetual Income & Growth Investment Trust plc ("Perpetual") that,
following the recent placing of shares by the Company, Perpetual is the
beneficial owner of 14,348,079 Ordinary Shares of 2p each in Protherics (4.23%
of the issued share capital of the Company).  The shares are registered in the
name of Vidacos Nominees Limited.

The issued share capital of the Company is 338,976,174 Ordinary Shares.

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For further information please contact:

Nick Staples, Director of Corporate Affairs                                     +44 (0) 7919  480510
Julie Vickers, Company Secretary                                                +44 (0)1928 518010

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