SOURCE: Protherics PLC

December 04, 2006 13:20 ET

Protherics PLC announces Interest in Shares

Cheshire, UK -- (MARKET WIRE) -- December 4, 2006 --

                                 Protherics PLC

                    Notification of Major Interest in Shares


London, UK; Brentwood, TN; 4 December 2006 - Protherics PLC ("Protherics" or the
"Company"), the international biopharmaceutical company focused on critical care
and cancer, announces that, on 1 December 2006, it received notification from
Barclays PLC that, as at 27 November 2006, Barclays PLC held an interest in
9,730,366 ordinary shares, representing 3.72% of the issued share capital of the
Company.



The issued share capital of the Company is 261,487,953 ordinary shares.



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For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs              +44 (0) 7919  480510
Julie Vickers, Company Secretary                           +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, David Yates                          +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                       +1 212 850 5600



Or visit  www.protherics.com


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