Protherics PLC announces Interest in Shares

Cheshire, UK -- (MARKET WIRE) -- January 17, 2007 --

                            Protherics PLC

                 Notification of major interest in shares



London, UK; Brentwood, TN, US; 17 January 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, today announces that, on 16 January 2007, notification was
received from Artemis Investment Management Limited that, following the increase
in the share capital of Protherics which took place on 4 January 2007, Artemis
Income as beneficial owners of the shares within Artemis Investment Management
Ltd, no longer have a notifiable interest in the shares of Protherics.



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For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs       +44 (0) 7919  480510
Julie Vickers, Company Secretary                  +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                   +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt           +1 212 850 5600



Or visit  www.protherics.com


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