SOURCE: Protherics PLC

January 08, 2007 13:26 ET

Protherics PLC announces Major Interest in Shares

Cheshire, UK -- (MARKET WIRE) -- January 8, 2007 --

                                 Protherics PLC

                    Notification of Major Interest in Shares

London, UK; Brentwood, TN, US; 8 January 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that notification was received today from Aviva plc
that, following the purchase of 3,738,187 Ordinary 2p shares in Protherics on 4
January 2007 (1.10% of the Company's issued share capital), Aviva plc and its
subsidiaries hold an interest in 40,095,830 Ordinary Shares (11.83%).

The shares are represented by a beneficial interest in 20,220,671 Ordinary
Shares (5.97%) and a non-beneficial interest in 19,875,159 Ordinary Shares

This notification follows the Company's recent Placing and Open Offer and is
based on an enlarged share capital of 338,976,174 Ordinary Shares.

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For further information please contact:

Nick Staples, Director of Corporate Affairs                 +44 (0) 7919  480510
Julie Vickers, Company Secretary                            +44 (0)1928 518010

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