SOURCE: Protherics PLC

November 23, 2007 13:26 ET

Protherics PLC announces Major Interest in Shares

Cheshire, UK--(Marketwire - November 23, 2007) -

                                 Protherics PLC

                   Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 23 November 2007 - Protherics PLC ("Protherics"
or the "Company"), the international biopharmaceutical company focused on
critical care and cancer, announces that on 22 November 2007, in accordance with
the Transparency Obligations Directive, a notification of interest in the
ordinary share capital of the Company was received from HBOS plc.  Details of
the interest notified are as follows:

1. Reason for the notification (please tick the appropriate box or boxes)

A disposal of voting rights                                       X

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the                                HBOS plc
notification obligation:

3. Full name of shareholder(s) (if different                       See Section 8
from 2.):

4. Date of the transaction (and date on which                   21 November 2007
the threshold is crossed or reached if

5. Date on which issuer notified:                               22 November 2007

6. Threshold(s) that is/are crossed or reached:        Decrease to below 6% Direct and Indirect

7. Notified details:

A: Voting rights attached to shares

Class/type of    Situation previous to the  Resulting situation after the triggering transaction
shares           Triggering transaction

if possible      Number of    Number of     Number of     Number of voting rights     % of voting rights
using the ISIN   Shares       Voting Rights shares
                                            Direct        Direct        Indirect      Direct    Indirect

Ord 2p Shares    20,918,307   20,918,307    1,308,983     1,308,983     18,936,943    0.386%    5.580%

ISIN GB000702920

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial    Expiration date Exercise/ Conversion     Number of voting rights    % of voting rights
instrument                           Period/ Date             that may be acquired if
                                                              the instrument is
                                                              exercised/ converted.

Total (A+B)

Number of voting rights                           % of voting rights

  20,245,926                                              5.966%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable:

Insight Investment Management (Global) Limited* ('IIMGL') - (Indirect) - 20,222,375 (5.959%)

IIMGL manages holdings on behalf of other HBOS Group companies, and other third parties external to the
HBOS Group, under various discretionary management agreements.

(* - wholly owned subsidiaries of HBOS plc).

Proxy Voting:

9. Name of the proxy holder:                                                             N/A
10. Number of voting rights proxy holder will cease to hold:                             N/A
11. Date on which proxy holder will cease to hold voting rights:                         N/A

12. Additional information:

                                     Notification using the total voting rights figure of

                                   |  Ends  |

For further information please contact:


Nick Staples, Director of Corporate Affairs               +44 (0) 7919  480510
Julie Vickers, Company Secretary                          +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                             +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                   +1 212 850 5600

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