Protherics PLC announces Offer Update


Cheshire, UK--(Marketwire - October 16, 2008) -


NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, IN
OR INTO OR FROM ANY JURISDICTION WHERE TO DO THE SAME WOULD CONSTITUTE
A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION


London, 16 October 2008


BTG PLC ("BTG") and PROTHERICS PLC ("PROTHERICS")


Offer update - Intended date of posting of Offer Documents


Further to the announcement of the recommended all share offer by BTG
for Protherics on 18 September 2008 (the "Recommended
Offer"), the board of BTG and the Independent Directors of Protherics
hereby announce that the Scheme Document relating to the Recommended
Offer will be sent to Protherics Shareholders on 17 October
2008, together with a copy of the BTG Prospectus relating to the New
BTG Shares to be issued in connection with the Recommended Offer.


At the same time, BTG will send a copy of the BTG Prospectus and the
BTG Circular to BTG Shareholders. 


Capitalised terms used but not defined in this announcement have the
same meanings as set out in the announcement dated 18 September 2008
referred to above.


Enquiries 


BTG

Christine Soden, Chief Financial Officer        Tel: 020 7575 0000

Andy Burrows, Director of Investor Relations


Protherics

Andrew Heath, Chief Executive Officer           Tel: 020 7246 9950

Rolf Soderstrom, Chief Financial Officer


Rothschild (financial adviser to BTG)

Dr Lynn Drummond                                Tel: 020 7280 5000


Jefferies (financial adviser to Protherics)

Ian Crosbie                                     Tel: 020 7029 8000

Chris Snoxall (corporate broking)


Piper Jaffray (joint broker and advisor to BTG)

Neil Mackison / Jamie Adams                     Tel: 020 3142 8700


Credit Suisse (joint broker and advisor to BTG)

Stephanie Leouzon / Tristan Lovegrove           Tel: 020 7888 8000


Nomura Code Securities (broker to Protherics)

Chris Collins                                   Tel: 020 7776 1200


Financial Dynamics

Ben Atwell                                      Tel: 020 7831 3113



Rothschild, which is authorised and regulated in the UK by the
Financial Services Authority, is acting as financial adviser and
sponsor to BTG in connection with the Recommended Offer and no-one else
and will not be responsible to anyone other than BTG for providing the
protections afforded to clients of Rothschild nor for providing advice
in relation to the Recommended Offer nor any other matter referred to
in this announcement.


Jefferies, which is authorised and regulated in the UK by the Financial
Services Authority, is acting as financial adviser and broker to
Protherics in connection with the Recommended Offer and no-one else and
will not be responsible to anyone other than Protherics for providing
the protections afforded to clients of Jefferies nor for providing
advice in relation to the Recommended Offer nor any other matter
referred to in this announcement.


                    This information is provided by RNS
          The company news service from the London Stock Exchange

END

Contact Information: Contacts: RNS Customer Services 0044-207797-4400 http://www.rns.com