Protherics PLC - Director/PDMR Shareholding


Cheshire, UK--(Marketwire - June 10, 2008) -


Protherics PLC


Notification of Interests

Directors and Persons Discharging Managerial Responsibility

London, UK; Brentwood, TN, US; 10 June 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, Protherics PLC announces
the grant, on 9 June 2008, of the following options over Ordinary
Shares in Protherics ("Ordinary Shares") to Directors and other Persons
Discharging Managerial Responsibility (PDMRs) under the terms of
the Protherics PLC Long Term Incentive Plan ("LTIP"): 


Name                 Position                                 Number
                                                              of Options
Directors:                                                         
Andrew Heath         Chief Executive Officer                  500,000
Rolf Soderstrom      Finance Director                         313,513
James Christie       Operations Director                      270,270
PDMRs:                                                             
Ian Scoular          Director of Business Development         227,027
Nick Staples         Director of Corporate Affairs            191,891
Sally Waterman       Director of Research & Development       227,027


The options are exercisable between the third and tenth anniversary of
the date of grant at an exercise price of 2p per share, subject to the
achievement of performance conditions.


Protherics also announces the award, on 9 June 2008, of a conditional
right to receive 252,460 Ordinary Shares under the terms of the
LTIP, to Saul Komisar, President of the Company's US operations.
The award vests on the third anniversary of the date of grant subject
to the achievement of performance conditions.  


In addition to the above, the following Directors and PDMRs were
granted options under the terms of the Deferred Bonus Plan on 9 June
2008:


	                      Number of
Directors:	                Options
Rolf Soderstrom	                 99,099
James Christie	                128,378
PDMRs:	
Sally Waterman	                 86,486
Nick Staples	                 72,972

The options are exercisable between the second and tenth anniversary of
the date of grant at an exercise price of 2p per share.

Following the above grant of options and share awards, the
Company's Directors and PDMRs hold options or share awards over the
following number of Ordinary Shares:


                           Number of Shares

Andrew Heath                      4,523,909
Rolf Soderstrom                   1,040,339
James Christie                    1,851,986
Saul Komisar                      1,523,541
Ian Scoular                       1,348,758
Nick Staples                        871,114
Sally Waterman                      993,023



                                / Ends /



For further information please contact:


Protherics 

Nick Staples, Director of Corporate Affairs   +44 (0) 7919 480510  
Julie Vickers, Company Secretary              +44 (0)1928 518010


Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                 +44 (0) 20 7831 3113 
New York: John Capodanno, Jonathan Birt       +1 212 850 5600


Or visit  www.protherics.com

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