SOURCE: Protherics PLC

June 12, 2006 12:57 ET

Protherics Plc - Holding(s) in Company -1

Cheshire, UK -- (MARKET WIRE) -- June 12, 2006 --

                           PROTHERICS PLC

              NOTIFICATION OF MAJOR INTERESTS IN SHARES

12 June 2006: Protherics PLC (the "Company"), the international biopharmaceutical company focused on critical care and oncology, received notification on 9 June 2006 from AXA Investment Managers UK Limited on behalf of AXA S.A. and its Group Companies ("AXA S.A.") that, as at 8 June 2006, AXA S.A. held an interest in 28,381,551 ordinary 2p shares (the "Shares") in the share capital of the Company (10.90%). The Company's current issued share capital is 260,295,464 ordinary shares.

The Shares are represented by a beneficial interest in 10,000 ordinary shares (0.004%) and a non-beneficial interest in 28,371,551 ordinary shares (10.90%).

This notification follows a decrease in total holding from 11.20% to 10.90%.

ENDS


For further information contact:

Protherics PLC                            +44 (0) 20 7246 9950
Julie Vickers, Company Secretary          +44 (0) 1928 518010
Nick Staples, Corporate Affairs           +44 (0) 7919 480510 (mobile)

Financial Dynamics                        +44 (0) 20 7831 3113
Ben Atwell/David Yates



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