SOURCE: Protherics PLC

June 12, 2006 13:04 ET

Protherics Plc - Holding(s) in Company - 2

Cheshire, UK -- (MARKET WIRE) -- June 12, 2006 --

                           PROTHERICS PLC

             NOTIFICATION OF MAJOR INTERESTS IN SHARES

12 June 2006: Protherics PLC ("the "Company"), the international biopharmaceutical company focused on critical care and oncology, received notification on 12 June 2006 on behalf of Perpetual Income & Growth Investment Trust plc ("Perpetual") that, following the purchase of 729,934 Ordinary Shares of 2p each in the Company ("Ordinary Shares") on 8 June 2006, Perpetual is the beneficial owner of 10,749,436 Ordinary Shares, representing 4.13% of the issued share capital of the Company. The shares which are the subject of this notification are registered in the name of Vidacos Nominees Limited.

The Company's current issued share capital is 260,295,464 ordinary shares.

ENDS

For further information contact:

Protherics PLC                            +44 (0) 20 7246 9950
Julie Vickers, Company Secretary          +44 (0) 1928 518010
Nick Staples, Corporate Affairs           +44 (0) 7919 480510 (mobile)


Financial Dynamics                        +44 (0) 20 7831 3113
Ben Atwell/David Yates





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