SOURCE: Protherics PLC

March 21, 2007 14:18 ET

Protherics Plc - Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- March 21, 2007 --

                            Protherics PLC

             Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 21 March 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that, on 20 March 2007, the following notification of
interest in the ordinary share capital of the Company was received from HBOS plc
pursuant to the Transparency Obligations Directive (Disclosure and Transparency
Rules) Instrument 2006:

1. Reason for the notification (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights
An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):  Initial notification under Transparency Directive         X

2. Full name of person(s) subject to the                                HBOS plc
notification obligation:

3. Full name of shareholder(s) (if different
from 2.):
                                                         See Section 8

4. Date of the transaction (and date on which            N/A
the threshold is crossed or reached if

5. Date on which issuer notified:                        20 March 2007

6. Threshold(s) that is/are crossed or reached:                               6%

7. Notified details:

A: Voting rights attached to shares

Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect

Ord 2p Shares     n/a         n/a          2,529,295     2,529,295     18,389,102    0.746%    5.423%



B: Financial Instruments

Resulting situation after the triggering transaction
Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.


Total (A+B)
Number of voting rights                           % of voting rights

  20,918,307                                              6.169%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments
are effectively held, if applicable :

Insight Investment Management (Global) Limited* ('IIMGL') - (Indirect) - 20,900,225 (6.163%)

IIMGL manages holdings on behalf of other HBOS Group companies, and other third parties external to the
HBOS Group, under various discretionary management agreements.

(* - wholly owned subsidiaries of HBOS plc).

Proxy Voting:

9. Name of the proxy holder:                                                       N/A

10. Number of voting rights proxy holder will cease to hold:                       N/A

11. Date on which proxy holder will cease to hold voting                           N/A

12. Additional information:


                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs    +44 (0) 7919  480510
Julie Vickers, Company Secretary               +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt        +1 212 850 5600

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