SOURCE: Protherics PLC

March 16, 2007 12:05 ET

Protherics PLC - Major interest in Shares

Cheshire, UK -- (MARKET WIRE) -- March 16, 2007 --

                         Protherics PLC

           Notification of Major Interests in Shares
London, UK; Brentwood, TN, US: 16 March 2007 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that the following notification of interest in the ordinary share capital of the Company was received on 15 March 2007 from M&G Investment Management Limited on behalf of Prudential plc pursuant to the Transparency Obligations Directive (Disclosure and Transparency Rules) Instrument 2006.
1. Reason for the notification (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights

An acquisition or disposal of financial instruments which may result in
the acquisition of shares already issued to which voting rights are
attached

An event changing the breakdown of voting rights

Other (please specify): CONFIRMATION OF CURRENT POSITION USING STANDARD
FORM AS REQUIRED BY EUTD REGULATIONS                                 X

2. Full name of person(s) subject to the       Prudential plc group
   notification obligation:                    of companies

3. Full name of shareholder(s) (if different
   from 2.):                                   Prudential plc
                                               Registered Holder: PRUCLT
                                               HSBC GIS NOM (UK) PAC AC
                                               The Prudential Assurance
                                               Company Limited
                                               Registered Holder: PRUCLT
                                               HSBC GIS NOM (UK) PAC AC

4. Date of the transaction (and date on which  14 March 2007
   the threshold is crossed or reached if
   different):

5. Date on which issuer notified:              15 March 2007

6. Threshold(s) that is/are crossed or reached: 3%

7. Notified details:

A: Voting rights attached to shares
Class/type of     Situation previous to    
shares            the Triggering
                  transaction
if possible using Number of   Number of    
the ISIN CODE     Shares      Voting       
                              Rights       
GB0007029209      11,229,430  11,229,430   



Class/type of     Resulting situation after the triggering transaction
shares
if possible using Number of  Number of voting rights   % of voting rights
the ISIN CODE     Shares     
                  Direct     Direct         Indrect    Direct    Indirect
GB0007029209      11,229,430 11,229,430                3.31%



B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial    Expiration date Exercise/ Conversion      
instrument                           Period/Date
N/A                  N/A             N/A                       

Resulting situation after the triggering transaction
Number of voting rights    % of voting rights
that may be acquired if
the instrument is
exercised/ converted.
N/A                  N/A       

Total (A+B)
Number of voting rights                           % of voting rights
11,229,430                                        3.31%

8. Chain of controlled undertakings through which the voting rights
   and/or the financial instruments are effectively held, if applicable :

Prudential plc (parent company)

The Prudential Assurance Company Limited (wholly owned subsidiary of
Prudential plc)

Proxy Voting:

9. Name of the proxy holder:                                  N/A

10. Number of voting rights proxy holder will cease to hold:  N/A

11. Date on which proxy holder will cease to hold voting      N/A
    rights:

12. Additional information:                                   None

                                Ends  

For further information please contact:

Protherics

Nick Staples, Director of Corporate Affairs      +44 (0) 7919  480510
Julie Vickers, Company Secretary                 +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                  +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt          +1 212 850 5600

Or visit  www.protherics.com

                      This information is provided by RNS
            The company news service from the London Stock Exchange