SOURCE: Xtalks

Xtalks Webinars

June 07, 2017 08:55 ET

Quantitative Protein Profiling in FFPE to Characterize Toxicities Associated with Immune Checkpoint Inhibitors, New Webinar Hosted by Xtalks

Joseph M. Beechem, PhD, Senior VP of Research & Development at NanoString Technologies and Justin Balko, PharmD, PhD, Assistant Professor of Medicine and Cancer Biology at Vanderbilt University Medical Center will discuss how NanoString Technologies characterize the immune composition of tissue affected by immune checkpoint inhibitor-mediated inflammation with a focus on colitis and neurologic toxicity

TORONTO, ON--(Marketwired - June 07, 2017) - The live event take places on Wednesday, June 21, 2017 at 12pm EDT.

Immune checkpoint inhibitors (including anti-CTLA-4 and anti-PD-1) have shown substantial clinical success in many cancers but have been linked to rare immune-related adverse events (irSAE). The molecular underpinnings of irSAE have not been extensively explored.

The development of a novel digital spatial profiling platform by NanoString Technologies enables deep molecular characterization of immune rich tissue using digital optical barcodes. FFPE validated antibodies are digitally barcoded using photocleavable DNA oligo tags to measure 30-50 proteins in tissue. Regions of interest (ROI), selected based on a fluorescence imaging scan of the entire tissue, were illuminated sequentially with focused UV light to release the oligos. Following each UV cycle, eluent was collected from the local ROI, moved to a microtiter plate, hybridized to NanoString® barcodes, and then analyzed with an nCounter® Analysis System.

To learn more about this complimentary presentation visit: Quantitative Protein Profiling in FFPE to Characterize Toxicities Associated with Immune Checkpoint Inhibitors

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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