SOURCE: Xtalks

Xtalks Webinars

April 23, 2015 07:05 ET

RNA Biomarker Development: From Sample to Insight, New Webinar Hosted by Xtalks

TORONTO, ON--(Marketwired - April 23, 2015) - Join presenters Eric Lader, Senior Director of Product Development at QIAGEN, and James Dear, Senior Clinical Lecturer in Clinical Pharmacology at Royal Infirmary of Edinburgh/Edinburgh University for an informative one-hour session that will include a Q&A with the audience. This webinar takes place on Wednesday, May 13, 2015 at 11am EDT / 4pm BST (UK GMT +1).

Precision medicine offers to transform patient care by targeting treatment to those with the most to gain. To date the most significant advances have been at the level of DNA, for example, the use of somatic DNA alterations as diagnostic indicators of disease and for prediction of pharmacodynamic response. Development of RNA expression signatures as biomarkers has been more problematic. While RNA expression analysis has yielded valuable insights into the biological mechanisms of disease, RNA is a more unstable molecule than DNA, and more easily damaged or degraded during sample collection and isolation. In addition, RNA levels are inherently dynamic and gene expression signatures are extraordinarily complex. Recently, much progress has been made in identifying key changes in gene expression in cancer and other diseases, as well as identifying expression signatures in circulating nucleic acid that have the potential to be developed into diagnostic and prognostic indicators.

In the first half of this webinar, Dr. Lader will review strategies for accessing the expression profiles of mRNA, lncRNA, and miRNA in both solid tissues and liquid biopsies. Sample handling, input requirements, nucleic acid isolation techniques, and profiling and data normalization strategies will be discussed.

Following this overview, Dr. Dear will describe the application of human micronome profiling in liquid biopsies to the development of an early minimally invasive biomarker for detection of early stage acetaminophen poisoning in patients. Acetaminophen poisoning is among the most common causes of medication-related poisoning and death. The maximum amount per diem for adults is 4 grams (4000 mg), a dose easily exceeded due to the inclusion of acetaminophen in many over the counter medicines. From cohort selection and sample collection, to expression profiling and data normalization, and finally, the development of a candidate miRNA expression signature which can be used as a surrogate marker, Dr. Dear will describe his progress in the development of a novel miRNA-signature based non-invasive biomarker.

To learn more about this event visit: RNA Biomarker Development: From Sample to Insight

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