SOURCE: SkyePharma PLC

April 17, 2007 11:58 ET

SkyePharma PLC announces Holding(s) in Company

London, UK -- (MARKET WIRE) -- April 17, 2007 --

                         SkyePharma PLC ("the Company")
                    Notification of Major Interest in Shares


In accordance with paragraph 5.1.2 of the Disclosure and Transparency Rules, the
Company has received a notification dated 13 April 2007 from Aviva plc and its
subsidiaries ("Aviva") stating that as at 11 April 2007, it held a notifiable
interest of 83,999,653 shares in SkyePharma PLC, which represents 10.31% of the
voting rights in the Company.  9.62% are held directly and 0.69% are held
indirectly.

Direct holdings:    BNY Norwich Union Nominees Limited   19,270,661 shares
                    Chase GA Group Nominees Limited      41,674,191 shares
                    Chase Nominees Limited               1,381,373 shares
                    CUIM Nominee Limited                 15,859,401 shares
                    Vidacos Nominees Limited             222,791 shares

                                                         78,408,417 shares (9.62%)

Indirect holdings:  Chase Nominees Limited               1,361,734 shares
                    CUIM Nominee Limited                 859,130 shares
                    Vidacos Nominees Limited             3,370,372 shares

                                                         5,591,236 Shares (0.69%)


Prior to the triggering transaction, Aviva held 43,183,326 Ordinary Shares and
notifies the Company that the percentage thresholds that have been crossed are
6% to 10% (inclusive) at the combined interest level.



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