SOURCE: Smith & Nephew PLC

February 15, 2006 07:42 ET

Smith & Nephew PLC announces Holding(s) in Company

London, UK -- (MARKET WIRE) -- February 15, 2006 --

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

Smith & Nephew plc

2. Name of shareholder having a major interest

The Capital Group Companies, Inc.

3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18

Non-beneficial

4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them

Capital Guardian Trust Company:

State Street Nominees Ltd 82,550

Bank Of New York Nominees Ltd 1,304,343

Chase Manhattan Bank Australia Ltd 8,500

Chase Nominees Ltd 6,815,456

BT Globenet Nominees Ltd 137,300

Midland Bank plc 194,900

Cede & Co 131,900

Deutsche Bank Mannheim 4,500

Bankers Trust 49,200

Nortrust Nominees 1,385,974

Royal Bank of Scotland 12,000

MSS Nominees Ltd 31,700

State Street Bank & Trust Co 51,100

RBSTB Nominees Ltd 9,700

Deutsche Bank AG 3,600

HSBC Bank plc 600

ROY Nominees Ltd 4,600

Mellon Nominees (UK) Ltd 337,900

HSBC 5,200

JP Morgan Chase Bank 907,333

Capital International Ltd:

State Street Nominees Ltd 9,200

Bank of New York Nominees 1,010,846

Northern Trust 376,344

Chase Nominees Ltd 658,145

Midland Bank plc 22,900

Citibank London 130,200

Morgan Guaranty 77,500

Nortrust Nominees 668,026

Royal Bank of Scotland 96,400

State Street Bank & Trust Co 69,000

National Westminster Bank 10,800

Deutsche Bank AG 282,841

HSBC Bank plc 265,565

Mellon Bank NA 28,700

KAS UK 8,900

Bank One London 31,300

Capital International SA:

Chase Nominees Ltd 83,900

Midland Bank plc 2,400

National Westminster Bank 10,200

Lloyds Bank 5,200

HSBC Bank plc 38,400

Capital Research and Management Company:

State Street Nominees Ltd 15,612,980

Chase Nominees Ltd 73,427,814

State Street Bank & Trust Co 159,710

Capital International Inc

Nortrust Nominees 23,000

HSBC Bank plc 11,500

5. Number of shares / amount of stock acquired

Not disclosed

6. Percentage of issued class

Not disclosed

7. Number of shares / amount of stock disposed

...............................................................

8. Percentage of issued class

...............................................................

9. Class of security

Ordinary shares of US 20 cents

10. Date of transaction

Not known

11. Date company informed

15.02.06

12. Total holding following this notification

104,600,127

13. Total percentage holding of issued class following this notification

11.19%

14. Any additional information

...............................................................

15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary

020 7960 2228

16. Name and signature of authorised company official responsible for making this notification

Phil Higgins - Assistant Company Secretary

Date of notification

15.02.06

The FSA does not give any express or implied warranty as to the accuracy of this document or material and does not accept any liability for error or omission. The FSA is not liable for any damages (including, without limitation, damages for loss of business or loss of profits) arising in contract, tort or otherwise from the use of or inability to use this document, or any material contained in it, or from any action or decision taken as a result of using this document or any such material.


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