SOURCE: Xtalks

Xtalks Webinars

August 16, 2017 07:00 ET

Solvents, Polymers & Cyclones -- Bioavailability Enhancement through Spray Dried Dispersions

TORONTO, ON--(Marketwired - August 16, 2017) - In an Xtalks webinar scheduled for Thursday, September 7, 2017 at 11am EDT (4pm BSK/UK), industry experts Stephie Lee, Associate Scientist at Catalent and Eric Gorman, Research Scientist II at Gilead Sciences, will introduce key spray dried dispersion development considerations allowing for identification of a stable prototype that will enhance and sustain in-vivo drug solubility. The discussion will include spray dried dispersion formulation development and early phase considerations for finished dose development.

An increasing number of new molecules in pipelines are poorly soluble, and more than ever applying a bioavailability enhancing technology early to enable exposure and efficacy is a key factor to success.

Amorphous dispersion development is a growing approach to improving the bioavailability of poorly soluble compounds. Spray drying is an established and growing technology for preparing amorphous dispersions.

Learning objectives:

  • Parameters that indicate amorphous spray dried dispersions are an optimal formulation approach
  • Pre-formulation studies to ensure successful development of spray dried dispersions
  • Best practices for formulation screening and evaluation of stability, performance, and manufacturability of spray dried dispersions
  • Preformulation solvent solubility screening and stability assessment
  • Rapid polymer screening for solubility enhancement
  • Screening of selected polymers and drug loads for physical and chemical stability
  • Excipient compatibility testing
  • In-vitro and in-vivo formulation screening
  • Critical quality attributes & keys to successful spray drying
  • Early phase finished dose formulation strategies for spray dried dispersions

To learn more information about this complementary event visit: Solvents, Polymers & Cyclones - Bioavailability Enhancement through Spray Dried Dispersions

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, to private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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