July 31, 2012 06:00 ET

SPRIM Announces Publication of Oral Health Clinical Study in Caries Research

SAN FRANCISCO, CA--(Marketwire - Jul 31, 2012) - SPRIM, a consulting firm and clinical research organization that partners with life science companies, announced today the publication of a clinical study in Caries Research, the premier journal in the dental caries field.

SPRIM, in collaboration with the Wrigley Company and the Affiliated Stomatology Hospital of Tongji University (Shanghai, China), conducted a prospective, cross-sectional study in 191 adults aged 18 to 65 years to determine the relationship between gum chewing habits and oral health. All subjects reported their gum chewing habits on a standard questionnaire and underwent a series of oral health tests including unstimulated salivary flow rate, salivary pH, and caries severity. 

The study results demonstrated that older adults had a lower unstimulated salivary flow rate, which is a known risk factor for caries development. More importantly, the authors reported that frequent gum chewing was associated with higher salivary flow rates and lower caries severity.

Professor XiaoPing Wang, professor at the Affiliated Stomatology Hospital of Tongji University and the principal study investigator, said, "Gum chewing on more days per week had a consistent relationship with elevated unstimulated salivary flow rate and lower caries severity."

Dr. Larry Miller of SPRIM, a coauthor of the study, said, "The results of this study provide strong evidence that frequent gum chewing may improve oral health by increasing salivary flow, particularly in the elderly who are especially prone to lower saliva production."

The study was recently published in Caries Research, internationally recognized as the premier dental caries journal and widely regarded as an indispensable source for both basic scientists and clinicians engaged in understanding, investigating and preventing dental disease.

SPRIM is an integrated, global health innovation centered firm, with consulting and clinical research practices that include: Strategy & Innovation (SI), Regulatory & Scientific Affairs (RSA), Research & Clinical Services (RCS), Health Marketing & Communications (HMC), and Issue & Quality Management (IQM), all designed to help our clients turn new technologies and scientific breakthroughs into winning products and concepts for human health. SPRIM brings a unique combination of scientific depth, regulatory expertise, clinical research capability, market understanding, and commercial experience, which are all important components of delivering outstanding, actionable deliverables for companies that innovate for human health.

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About Wrigley

Wrigley is a recognized leader in confections with a wide range of product offerings including gum, mints, hard and chewy candies, and lollipops. Wrigley's world-famous brands -- including Extra®, Orbit®, Doublemint®, and 5™ chewing gums, as well as confectionery brands Skittles®, Starburst®, Altoids® and Life Savers® -- create simple pleasures for consumers every day. With operations in more than 40 countries and distribution in more than 180 countries, Wrigley's brands bring smiles to faces around the globe. The company is headquartered in Chicago, Illinois, employs approximately 17,000 associates globally, and operates as a subsidiary of Mars, Incorporated. Based in McLean, Virginia, Mars has net sales of more than $30 billion, six business segments including Petcare, Chocolate, Wrigley, Food, Drinks, Symbioscience, and approximately 70,000 Associates worldwide that are putting our Mars Principles into action to make a difference for people and the planet through our performance.

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