SOURCE: Xtalks

Xtalks Webinars

November 20, 2014 07:05 ET

Sugar Modified Nucleosides and Nucleotides -- The Synthesis of Anti-Viral Drugs, Live Webinar Hosted by Xtalks

TORONTO, ON--(Marketwired - November 20, 2014) - Join the panel from Peakdale Molecular including Group Leaders Dr. Nigel Allanson and Dr. Mark Betson, and Lead Chemist Dr. Steve Moore. The live broadcast will take place on Thursday, December 4, 2014 at 11am EST (4pm GMT).

The development of antiviral drugs has been spurred by a major global health issue; the emergence of new viruses over the last 35 years. The number of people affected by these diseases is staggering, leading to the development of breakthrough antiviral drugs. According to the World Health Organisation, the HIV virus is estimated to have caused 36 million deaths and there are an estimated 35 million people currently living with AIDS. Hepatitus C Virus (HCV), first identified in 1989, is estimated to have infected almost 3% of the World's population, that's 150-200 million people.

The response of the pharmaceutical industry to these threats has been rapid. Breakthrough antiviral drugs, such as Tenofovir and Sofosbuvir, are transforming the prognosis for newly infected patients. These antiviral drugs would not exist if it wasn't for the skill and ingenuity of medicinal and organic chemists in inventing methods for the synthesis of nucleoside analogues.

This webinar will feature two presentations: The first will be a review of some of the most important synthetic strategies that allow chemists to make key structural changes to the sugar-portion of nucleosides. The second presentation will showcase a recent medicinal chemistry program carried out by Peakdale Molecular in partnership with Idenix Pharmaceuticals. This program is focused on the development of experimental nucleoside analogues containing locked nucleic acids for the treatment of HCV and will highlight the problems nucleoside chemists face when working to develop new antiviral drugs.

Key Learning Objectives:

  • Discussion and key references for the synthesis of sugar modified nucleosides, focusing on the 4'- and 2'-positions
  • Discussion of the syntheses of the sugar portions of the antiviral drugs, Sofosbuvir and Tenofovir
  • Presentation of a successful synthetic campaign to access conformationally locked nucleosides and nucleotides and a discussion of their activity against HCV NS5B polymerase

To learn more about this event visit: Sugar Modified Nucleosides and Nucleotides - The Synthesis of Anti-Viral Drugs

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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