Faculty of 1000

Faculty of 1000

June 12, 2012 09:15 ET

The First Day of Development--a Window to Successful Pregnancy

LONDON, UNITED KINGDOM--(Marketwire - June 12, 2012) - An article published in F1000 Biology Reports (http://f1000.com/reports/b/4/11/) discusses recent important advancements in the development of alternative methods of embryo evaluation and selection that could lead to improvements in the reliability of IVF treatments.

The success rate of in vitro fertilization (IVF) procedures still remains relatively low, at only around 30%. The high emotional, health and financial costs associated with having to undergo the procedure multiple times has driven the need to develop more efficient methods of assessing the development potential of embryos to ensure that only those with the highest potential are selected for IVF treatment.

In their article Advances in embryo selection methods for F1000 Biology Reports, F1000 Faculty Member in Development Biology Magdalena Zernicka-Goetz, and her Associate Faculty Member Anna Ajduk, compare the various methods currently used for assessing embryonic viability and discuss novel procedures based on advanced time-lapse imaging techniques. These new methods show signs of promise for increasing the efficiency and success of IVF treatments.

The authors argue that by developing more reliable methods of assessing embryonic quality, single embryos can be selected for transfer, which could reduce emotional costs, limit the impact on the health of mothers-to-be and improve the overall efficiency of the procedure. The authors say that reliable selection of high quality single embryos can be achieved by combining current screening methods with non-invasive time-lapse imaging techniques.

Commenting on her findings, Magdalena Zernicka-Goetz said: "This is a very effective, rapid and non-invasive way of assessing the health of mammalian embryos. I would be delighted if it can save the lives of human embryos, and I believe it should when applied in the IVF clinic."

Evidence of improvement in live birth outcomes still has to be determined by testing these methods in a clinical environment and subjecting them to randomized controlled trials; however, they offer great hope for more reliable assessment of embryonic quality and more efficient IVF treatments.

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Faculty of 1000 (http://f1000.com) is a post-publication review service in Biology and Medicine that identifies and evaluates the most interesting and important papers published worldwide. The core of our service is our 10,000 Faculty Members and Associates, who cover some 350 defined specialty sections and collectively contribute around 1300-1500 article evaluations per month. These evaluations are published immediately on F1000 and constitute an up-to-date and comprehensive guide to the best of the scientific literature.

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Magdalena Zernicka-Goetz

Magdalena Zernicka-Goetz is an F1000 Faculty Member in Developmental Biology and Professor of Developmental Biology in the Department of Physiology, Development and Neuroscience, at the Gurdon Institute, University of Cambridge, Cambridge, UK.

Anna Ajduk

Anna Ajduk is an F1000 Associate Faculty Member in Developmental Biology and works with Magdalena Zernicka-Goetz at the Gurdon Institute, University of Cambridge, Cambridge, UK, to evaluate the literature relevant to their research interests.

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