TORONTO, ON--(Marketwired - October 18, 2016) - In this presentation Dr. Lynn Webster, Vice President of Scientific Affairs (Early Development Services), and Michael Marschler, Director of Safety and Risk Management, both from PRA Health Sciences, will discuss how pharmacogenetics can be integrated in clinical trials. The speakers will also outline post-marketing settings to achieve a personalized therapy and how considering missing information (potential risk(s)) of genomic variations can help to identify risk minimization measures to greatly reduce the risk of side effects and significantly increase the therapeutic benefit to the patients.
Evidence suggests that there is a genetic influence on the prevalence and processing of pain. Pharmacogenetics therapy in pain patients requires the consideration of two different genetic substrates to determine the outcome of pharmacotherapy. The first being the genetic contribution to a variety of different pain types and the second is the genetic influence on drug effectiveness and safety. Furthermore, due to gene-environmental interactions there exists large variability in responses to drug therapy, some of which are inherited or non-inherited characteristics of the genome. Such genomic variations have the potential to lead to subsets of patients with a different benefit/risk profile.
The live broadcast takes place on Monday, October 31, 2016 at 11am EDT (3pm GMT). For more information or to register for this free webinar, visit: Pharmacogenetics in Pain Management and the Use of Pharmacogenomics Methodologies in the Pharmacovigilance Evaluation of Medicinal Products
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