SOURCE: Xtalks

Xtalks Webinars

November 20, 2015 08:29 ET

Upcoming Webinar to Examine the Structural Basis for HCV RNA Replication and Inhibition by Sofosbuvir

TORONTO, ON--(Marketwired - November 20, 2015) - On Tuesday, December 8, 2015, Xtalks will host a complimentary webinar featuring Thomas E. Edwards, Vice President of Structural Biology at Beryllium Discovery Corp., as the keynote speaker. This webinar will focus on how the HCV RNA polymerase replicates the HCV RNA genome starting with basic biology continuing through Beryllium's structural mechanistic studies with native substrates and nucleotide analog inhibitors such as sofosbuvir.

The hepatitis C virus (HCV) can cause chronic liver disease and is the major cause of liver transplantation in the US. Recently, the nucleotide analog inhibitor sofosbuvir was approved by the FDA for treatment of chronic HCV (N. Engl. J. Med. 2013, 368, 34). Sofosbuvir is incorporated into the replicating RNA genome via the viral RNA-dependent RNA polymerase (RdRp) and blocks the incorporation of additional nucleotides thereby inhibiting HCV genomic replication.

To understand on the atomic level how the HCV RdRp replicates the HCV genome and how it recognizes nucleotide analog inhibitors, investigators at Beryllium and Gilead Sciences determined crystal structures of stalled ternary complexes of HCV polymerase in complex with RNA primer-template pairs and nucleotides such as native substrates and nucleotide analog inhibitors. The findings of this collaboration were published Science earlier this year (Appleby, T.C. et al. Science, 2015, 347, 771).

For more information or to register for this free webinar visit: Structural Basis for HCV RNA Replication and Inhibition by Sofosbuvir

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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