SOURCE: Xtalks

Xtalks Webinars

June 26, 2017 07:30 ET

Vascular and Neural Complications in Rodent Models of Obesity and Type 2 Diabetes, New Webinar Hosted by Xtalks

In a live session on Wednesday, July 12, 2017 featured speaker Dr. Mark Yorek, Professor of Medicine at University of Iowa and Associate Chief of Staff for Research at Iowa City VA, will present vascular and neural complications in rodent models of obesity and type 2 diabetes. Specifically, he will present the characterization of peripheral neuropathy in translational animal models such as the ZDSD rat

TORONTO, ON--(Marketwired - June 26, 2017) - Peripheral neuropathy affects about 50% of the diabetic population. The manifestations range from pain, numbness, paresthesia and ulceration in the extremities and it is the major cause of non-traumatic amputations. Other than good glycemic control, which is non-effective for subjects with type 2 diabetes, there is no treatment for diabetic peripheral neuropathy. With the prevalence of obesity and type 2 diabetes and associated complications reaching epidemic levels, there is a critical need for finding a treatment to preserve and perhaps restore nerve function.

Studies of obese and diabetic animal models, primarily rodents, have been employed for many years to further our understanding of peripheral neuropathy and to seek an effective treatment. The traditional endpoints for diabetic neuropathy in animal and human studies have been nerve conduction velocity, nerve biopsies and quantitative sensory testing. However, translation of results from animal studies has not led to an effective treatment.

Attendees will learn about:

  • Challenges in translational modeling of vascular and neural complications in the context of obesity and type 2 diabetes
  • Rodent models of diabetes that have been used in the past to examine the development, progression, and potential treatment of diabetic peripheral neuropathy (eg., the Zucker and Zucker Diabetic Fatty [ZDF] rats)
  • Characterization of peripheral neuropathy and vascular complications in the diabetic ZDSD rat
  • Neural complications such as motor and sensory deficits in diabetic ZDSD rats
  • New endpoints that may improve translation of results from the bench to the bedside

The complimentary webinar benefiting pharmaceutical and biotechnology companies, non-profit organizations and academia working within diabetes research, includes a Q&A with the audience. For more information or to register visit: Vascular and Neural Complications in Rodent Models of Obesity and Type 2 Diabetes

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